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Circular Insulin

Recently two publications emphasized the expression of circular RNAs from Insulin genes in humans and mice. Especially the intron 2 of human insulin and mouse insulin2 gene forms stable circRNAs and are termed as ci-INS and ci-Ins2. It was shown to regulate insulin secretion by binding to TARDBP.


Cdr1as (also termed as ciRS-7) is generated from antisense transcript of cerebellum degeneration-related antigen 1 (CDR1).


CircHIPK3 is one of the most abundant circRNA expressed in a variety of cells including pancreatic β cells. CircHIPK3 is generated from the exon2 of HIPK3 mRNA by backsplicing


As the name indicates circAFF1 is produced from the AFF1 gene.

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